Cisplatin or Carboplatin and Sorafenib in Treating Patients With Liver Cancer That Cannot Be Removed By Surgery
Status:
Completed
Trial end date:
2012-06-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as cisplatin and carboplatin, work in different
ways to stop the growth of tumor cells, either by killing the cells or by stopping them from
dividing. Sorafenib may stop the growth of tumor cells by blocking some of the enzymes needed
for cell growth and by blocking blood flow to the tumor. Infusing chemotherapy directly into
the liver and giving it together with sorafenib may kill more tumor cells.
PURPOSE: This phase II trial is studying the side effects of infusing cisplatin or
carboplatin directly into the liver and giving it together with sorafenib in treating
patients with liver cancer that cannot be removed by surgery.
Phase:
Phase 2
Details
Lead Sponsor:
University of Miami University of Miami Sylvester Comprehensive Cancer Center