Cisplatin and Paclitaxel With or Without Everolimus in Treating Patients With Stage II or Stage III Breast Cancer
Status:
Completed
Trial end date:
2014-10-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as cisplatin and paclitaxel, work in different
ways to stop the growth of tumor cells, either by killing the cells or by stopping them from
dividing. Everolimus may stop the growth of tumor cells by blocking some of the enzymes
needed for cell growth and by blocking blood flow to the tumor. Giving chemotherapy together
with everolimus before surgery may make the tumor smaller and reduce the amount of normal
tissue that needs to be removed. It is not yet known whether cisplatin and paclitaxel are
more effective when given together with or without everolimus in treating patients with
breast cancer.
PURPOSE: This randomized phase II trial is studying how well cisplatin and paclitaxel work
when given together with or without everolimus in treating patients with stage II or stage
III breast cancer.