Cipralex in Treatment of Depressive Symptoms and Chronic Back Pain
Status:
Withdrawn
Trial end date:
2012-11-01
Target enrollment:
Participant gender:
Summary
Chronic low back pain (CLBP) is one of the most frequent forms of chronic pain and can result
in significant functional impairment. This is often associated with major depression too.
Previous research reported significant beneficial effects of antidepressant medication in
alleviating depression and pain intensity. The aim of this study is to evaluate the efficacy
of Escitalopram, a new kind of Selective Serotonin Reuptake Inhibitor (SSRI) in patients with
CLBP in a prospective, randomized and double-blind clinical trial. The main hypothesis is:
-in comparison to placebo, subjects with CLBP and Cipralex report a significant reduction in
depressive symptoms (>= 50% of HAMD questionnaire) after 4 weeks of treatment.