Overview

Chronomodulated Chemotherapy Followed by Concurrent Chemo-radiotherapy With IMRT in the Treatment of Advanced Nasopharyngeal Cancer

Status:
Unknown status
Trial end date:
2018-06-01
Target enrollment:
0
Participant gender:
All
Summary
1. Observe and compare the chrono-chemotherapy IMRT and conventional chemotherapy and intensity modulated radiotherapy term efficacy of the treatment of locally advanced nasopharyngeal carcinoma. 2. Evaluation chrono-chemotherapy IMRT and conventional chemotherapy and intensity modulated radiotherapy in locally advanced nasopharyngeal carcinoma safety and tolerability. 3)observing the adverse reaction and effects of two groups,expected chrono-chemotherapy group can achieve lower toxicity, improve the curative effect, for the treatment of nasopharyngeal carcinoma provides a more reasonable way.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Guiyang Medical University
Collaborators:
Sun Yat-sen University
The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University
Treatments:
Cisplatin
Criteria
Inclusion Criteria:

- initial treatment of advanced nasopharyngeal carcinoma Ⅲ-Ⅳ patients with
pathologically confirmed (according to 2010 UICC staging, T3-4, N0-3), without
evidence of distant metastasis (M0). Have measurable tumor lesions.

- KPS≥70 points.

- the age of 18-70 years old, male or female.

- no major organ dysfunction; normal bone marrow function (WBC ≥4.0 × 109 / L, platelets
≥100 × 109 / L, hemoglobin ≥90g / L), normal liver function (total bilirubin, alanine
aminotransferase, aspartate aminotransferase ≤1.5 times the upper limit of normal),
normal renal function (creatinine ≤ 1.5 times upper limit of normal).

- understand this study and signed informed consent.

Exclusion Criteria:

- distant metastasis.

- who had received prior chemotherapy.

- patients have physical or mental illness, and by researchers believe that patients can
not be completely or fully understood in this study possible complications.

- pregnancy (via the urine or serum β-HCG test confirmed) or during lactation.

- serious complications, such as uncontrolled hypertension, heart failure, diabetes and
so on.