Chronic Treatment With Benfotiamine Restores Endothelial Function in People With Type 2 Diabetes Mellitus
Status:
Unknown status
Trial end date:
2008-12-01
Target enrollment:
Participant gender:
Summary
An AGE-rich diet can induce after 2-6 weeks persistent increases in mediators linked to
vascular dysfunction (e.g. TNFα, VCAM-1) in people with type 2 diabetes mellitus (T2DM).
Benfotiamine (BT), the liposoluble derivative of vitamin B1, blocks several pathways common
to hyperglycaemia- and AGE-induced endothelial dysfunction. We have shown that advanced
glycation end products (AGE) of a regular mixed meal can acutely induce vascular dysfunction
in T2DM and that this effects can be prevented by a three days pretreatment with BT.
The hypotheses of this study are that chronical treatment with benfotiamine (900 mg/day for 6
weeks) in people with type 2 diabetes mellitus:
1. prevents postprandial impairment of endothelial function after a high-AGE meal.
2. Improves fasting endothelial function.
3. Improves parameters of autonomic function in fasting and postprandial state.
4. Improves insulin sensitivity and prevents postprandial increase in insulin resistance.