Chronic Effects of Estrogen in Microcirculation

• Status: Completed
• Trial end date: 2013-04-01
• Target enrollment: 0
• Participant gender: Female

Summary

This study aims to evaluate the chronic effects of estrogen on microcirculation, inflammatory biomarkers, hormonal status, plasma viscosity and biochemical tests in postmenopausal obese women after three months of follow-up intervention.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rio de Janeiro State University
• Treatments: Estrogens

Criteria

Inclusion Criteria:

• History of natural menopause defined by the absence of menses for at least 12 months and a serum concentration of FSH > 35 IU/L

• BMI between 27 to 34.9 kg/m²

• Non-smokers

• Not on use of any hormones or supplements for a minimum of 6 months prior to the study

• No absolute contraindications to the use of physiological replacement doses of estrogen

Exclusion Criteria:

• Renal disease, coronary or peripheral vascular diseases, haematologic or hepatic diseases

• Diabetes mellitus, glucose intolerance or altered fasting glucose