Chronic Bladder Pain Syndrome in Women: Can Doxycycline Help? A Prospective Study
Status:
Terminated
Trial end date:
2015-03-01
Target enrollment:
Participant gender:
Summary
Chronic bladder pain syndrome is a chronic disabling disorder characterized by chronic pelvic
pain, pressure or discomfort perceived to be related to the urinary bladder accompanied by at
least one other urinary symptom such as persistent urgency or frequency in the absence of an
identifiable cause. Chronic bladder pain syndrome severely decreases an individual's quality
of life and represents a significant financial burden to those affected by it. Currently,
multifactorial pathogenesis is assumed including endocrine-involvement, pelvic floor muscle
irregularities, immunologic aspects and chemical causes. Corresponding to the wide spectrum
of presumptive triggers, a large number of therapeutic approaches are propagated, however
most are associated with limited effectiveness. Thus, treatment of BPS is a challenge and the
ideal therapy remains to be elucidated. Microorganisms such as Chlamydia trachomatis,
Ureaplasma urealyticum and Mycoplasma genitalium remains a challenge so that these organisms
may well be involved in the pathogenesis of chronic bladder pain syndrome. The investigators
hypothesise that doxycycline orally for 4 weeks, including therapy of the sexual partner, can
significantly relieve symptoms in women with chronic bladder pain syndrome