Chronic Angiotensin Converting Enzyme Inhibitors in Intermediate Risk Surgery
Status:
Completed
Trial end date:
2016-12-01
Target enrollment:
Participant gender:
Summary
Primary research hypothesis: Patients who continue their chronic ACEI therapy up to and
including the morning of a non-cardiac, non-vascular surgery will experience more
intraoperative hypotension than those who transiently hold their chronic ACEI preoperatively.
Secondary research hypothesis #1: Patients who continue their chronic ACEI up to and
including the morning of a non-cardiac, non-vascular surgery will experience better
postoperative control of hypertension than those who transiently hold their chronic ACEI
preoperatively.
Secondary research hypothesis #2: Patients who continue their chronic ACEI up to and
including the morning of a non-cardiac, non-vascular surgery will experience less acute renal
failure than those who transiently hold their chronic ACEI preoperatively.
Secondary research hypothesis #3: In the subgroup of patients with a preoperative systolic
blood pressure less than 110 mmHg, those who continue their chronic ACEI therapy up to and
including the morning of a non-cardiac, non-vascular surgery will experience more
intraoperative hypotension than those who transiently hold their chronic ACEI preoperatively.
Secondary research hypothesis #4: In the subgroup of patients above the age of 64, those who
continue their chronic ACEI therapy up to and including the morning of a non-cardiac,
non-vascular surgery will experience more intraoperative hypotension than those who
transiently hold their chronic ACEI preoperatively.