Cholesterol Lowering Treatment With Psyllium Husks and Isolated Soy Protein in Hypercholesterolemia
Status:
Completed
Trial end date:
2012-01-01
Target enrollment:
Participant gender:
Summary
Despite improved treatment, cardiovascular disease remains one of the most common diseases
and causes of death in the Western world. Hypercholesterolemia is a well known risk factor
for developing cardiovascular disease. Prevention and treatment are based in part on lowering
LDL cholesterol. Dietary and lifestyle changes always play an important part of the treatment
and preventive effort, and conversion to a heart-healthy diet reduces LDL cholesterol by a
mean 10%. Further lowering of LDL cholesterol by means of food supplements have been
demonstrated in numerous studies. Cholesterol lowering food supplements include isolated soy
protein and water soluble dietary fibre such as psyllium husks. Postulated mechanisms of
action responsible for the cholesterol lowering in these two food supplements are different,
so there is a reason to expect an additive cholesterol lowering effect during concomitant
treatment with both substances. The investigators want to investigate whether concomitant
treatment with psyllium husks and isolated soy protein in addition to a heart-healthy diet
results in a significantly greater reduction of LDL cholesterol in hypercholesterolemia, than
single treatment with each of the substances.
Phase:
Phase 4
Details
Lead Sponsor:
Aalborg Universitetshospital Aalborg University Hospital