Cholecalciferol on Depressive Symptoms in Type 2 Diabetes Mellitus Patients
Status:
Recruiting
Trial end date:
2021-10-01
Target enrollment:
Participant gender:
Summary
One in eleven adults falls ill with Diabetes Mellitus (DM) and 90% of them suffered from type
2 DM. Depression in type 2 DM patients had a big impact, acting as a major barrier to
self-care in type 2 DM patients. Depression in diabetes patients is also associated with
decreasing quality of life. Poor self-care behavior and adherence, poor glycemic control, and
increased risk of mortality about 36-38% from cardiovascular complications are other known
debilitating results.
Vitamin D receptors are present in many organ systems, namely the pancreas, intestine,
musculoskeletal, and nervous systems. Vitamin D has pleiotropic effects, which were seen from
its mechanism as an anti-inflammatory, anti-apoptotic, and immunomodulatory agent. Based on
the mechanism of Vitamin D action in the nervous system, which also plays a role in
depression pathogenesis, vitamin D is hypothesized to have a beneficial effect on depression,
both for depression prevention and treatment. Few studies denote that Vitamin D can improve
depression in type 2 DM patients. Vitamin D may become an important adjuvant therapy to
ameliorate depression in type 2 DM patients. These clinical trials concerning vitamin D in
type 2 DM are relevant, reminding that type 2 DM resulted in higher morbidity, mortality, and
numerous high-risk complications in the population.