Overview

Chloroquine in Combination With Carboplatin/Gemcitabine in Advanced Solid Tumors

Status:
Completed
Trial end date:
2018-12-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this research study is to test the safety of chloroquine in combination with carboplatin and gemcitabine and see what effects (good and bad) it has on advanced solid tumors. Also, the research study will be increasing the dose of chloroquine to find the highest dose of chloroquine that can be given in combination with carboplatin and gemcitabine without causing severe side effects.
Phase:
Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Cincinnati
Treatments:
Carboplatin
Chloroquine
Chloroquine diphosphate
Gemcitabine
Criteria
Inclusion Criteria:

- Histologically confirmed diagnosis of a malignancy that is metastatic or unresectable
and for which either standard curative measures do not exist or are no longer
effective and carboplatin/gemcitabine is considered a reasonable treatment option
whether first line or acceptable and approved combination therapy.

- Age >18 years of age.

- Performance status less than or equal 2 (Karnofsky >60%)

- Life expectancy of greater than 3 months.

- Adequate labs

- Measurable disease

Exclusion Criteria:

- Current treatment with any other investigational agents.

- Patients with untreated brain metastases

- History of allergic reaction attributed to compounds of similar chemical or biologic
composition to chloroquine or other agents used in study.