Chloroquine Phosphate Prophylactic Use in Health Personnel Exposed to COVID-19 Patients

• Status: Not yet recruiting
• Trial end date: 2021-01-31
• Target enrollment: 0
• Participant gender: All

Summary

The primary objective of this study is to evaluate the efficacy and security of chloroquine phosphate prophylactic use for reducing the risk of infection by severe acute respiratory syndrome coronavirus-2 in Health Care Workers exposed to COVID-19 patients.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: CMN "20 de Noviembre"
• Treatments: Chloroquine; Chloroquine diphosphate

Criteria

Inclusion Criteria:

• Health Care Workers as first line of hospital care exposed to COVID-19 patients.

• Initial polymerase chain reaction assay negative test for severe acute respiratory syndrome coronavirus-2 infection.

• Both sexes

• Agree to participate in the study after signing an informed consent letter.

Exclusion Criteria:

• Health Care Workers as first line of hospital care exposed to COVID-19 patients with history of heart disease, arrhythmias or QT segment prolongation.

• Health Care Workers as first line of hospital care exposed to COVID-19 patients with liver or kidney disease of any etiology.

• Health Care Workers as first line of hospital care exposed to COVID-19 patients with retinopathy of any etiology.

• Health Care Workers as first line of hospital care exposed to COVID-19 patients with allergy to chloroquine.

• Health Care Workers as first line of hospital care exposed to COVID-19 patients with a history or diagnosis of psoriasis.

• Health Care Workers as first line of hospital care exposed to COVID-19 patients with important primary clinical alterations: renal (creatinine> 3), liver (Alanine Aminotransferase and Aspartate Aminotransferase x 3), endocrine, neurological.