Chloroquine Outpatient Treatment Evaluation for HIV-Covid-19
Status:
Withdrawn
Trial end date:
2021-06-30
Target enrollment:
Participant gender:
Summary
Clinical manifestations of Covid-19 are poorly characterised in HIV co-infection, which may
predispose to more severe disease. Reducing hospitalisation and severe illness in this
population has important individual and public health benefits. The investigators propose a
pragmatic multi-centre, randomized controlled trial in South Africa to evaluate the efficacy
and safety of chloroquine or hydroxychloroquine to prevent progression of disease and
hospitalisation amongst HIV-positive people with Covid-19 not requiring hospitalisation at
initial assessment.