Chloroquine Alone or in Combination for Malaria in Children in Malawi
Status:
Completed
Trial end date:
2012-09-01
Target enrollment:
Participant gender:
Summary
Malaria is a sickness caused by a germ that can get into a person's body when a mosquito
bites them. It can cause fever, headache, body aches and weakness. It can even cause death,
especially in children. When malaria is treated with the appropriate medicine(s), it can be
cured completely. The purpose of this study is to find out if it is better to use chloroquine
alone or in combination with another drug to most effectively treat malaria. About 640
children with malaria, aged 6 months to 5 years of age, from the Blantyre Malaria Project
Research Clinic at the Ndirande Health Center in Malawi will be in the study. They will be
treated with either chloroquine alone or a combination of chloroquine plus another medication
(azithromycin or artesunate or atovaquone-proguanil) every time they get malaria for a year.
Blood samples will be collected and tested at least every 4 weeks. Participants will be
involved in the study for 1 year.
Phase:
Phase 3
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)