Chinese Medicine for Treating Chronic Pharyngolaryngitis

• Status: Not yet recruiting
• Trial end date: 2025-07-31
• Target enrollment: 0
• Participant gender: All

Summary

A randomized, double-blinded, placebo-controlled clinical trial using a Chinese Medicine formula in treating Chronic pharyngolaryngitis. Subjects will be randomized into a treatment group or placebo group for 8 weeks, and then followed by an 8-week post-treatment visit.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Chinese University of Hong Kong

Criteria

Inclusion Criteria:

• 18 years of age or above (Chinese subjects only);

• Persistent symptoms of pharyngitis (sore throat, globus, dry throat, dry cough, throat irritation) for more than 3 weeks;

• Determined to be the following Chinese medicine syndromes by Registered Chinese Medicine Practitioners (RCMPs): Wind-heat invading the upper-jiao, or phlegm heat or Yin deficiency;

• Visual analog scale (VAS) score for pain ≥ 50 mm;

• Numeric rating scale (NRS) ≥ 6; and

• Be able to give voluntary written informed consent.

Exclusion Criteria:

• Known severe medical conditions, such as cardiovascular, liver or renal dysfunction, diabetes mellitus, cancers, cerebrovascular diseases, blood system diseases;

• Concomitant use of steroids, nonsteroidal anti-inflammatory drugs (NSAIDs), anticoagulants, and immunotherapy within the past week;

• Impaired hematological profile and liver / renal function exceed the upper limit of the reference value by 2 times;

• Known Allergic rhinitis;

• Known Gastroesophageal Reflux Disease (GERD);

• Known cancer or suspected cancer of throat/oesophagus;

• Mechanical obstruction of the throat accountable for the symptoms;

• Known alcohol and/or drug abuse;

• Known allergic history to any Chinese herbal medicines; and

• Subjects who are known pregnant or lactating.