Chinese Longitudinal and Systematic Study of Bioplar Disorder
Status:
Recruiting
Trial end date:
2026-12-31
Target enrollment:
Participant gender:
Summary
Affective disorders (mainly including major depressive disorder and bipolar disorder) are
common, chronic and highly disabling mental disorders, which lack of objective biological
markers. It is believed that genetic and environmental factors are involved in the
development of affective disorders. Gut microbes can affect the function of brain neural
circuits by mediating metabolic, immune, endocrine and autonomic changes along the brain-gut
axis. The brain can also regulate intestinal microbes through endocrine, neural structure,
neurogenic exosomes and other pathways. Based on the brain-gut axis, this study intends to
establish a large cohort of affective disorders, and screen out efficient and convenient
biomarkers for clinical diagnosis and efficacy prediction by studying key indicators such as
intestinal microbes, serum metabolites and immune indexes, brain-derived exosomes, and brain
functional imaging.