Overview

Chinese First Episode Schizophrenia's Optimal Dynamic Antipsychotic Treatment Regime

Status:
Unknown status
Trial end date:
2021-09-01
Target enrollment:
0
Participant gender:
All
Summary
This project is mainly to clarify the optimal treatment plan and the treatment recommendation sequence of different drugs in Chinese first-episode schizophrenia patients,to identify the optimized sequential treatment regimen for the treatment of resistance patients and provide new evidence for the revision of the guidelines for the treatment of schizophrenia.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Shanghai Mental Health Center
Treatments:
Amisulpride
Antipsychotic Agents
Aripiprazole
Olanzapine
Paliperidone Palmitate
Risperidone
Sultopride
Criteria
Inclusion Criteria:

- Meet the diagnostic criteria of Diagnostic and Statistical Manual Diploma in Social
Medicine(DSM-V) schizophrenia or schizophreniform psychosis

- Patient interview using the MINI-International Neuropsychiatric Interview(MINI 7.0)

- 18 to 40 years of age

- First episode, disease course less than 3 years

- Antipsychotic naïve, or the time of taking the same type of antipsychotic <2 weeks (2
weeks is a time criterion to determine the efficacy in lots of studies), and
cumulative antipsychotic drug exposure time <6 weeks Informed consent.

In addition, the severity of psychiatric symptoms is moderate or above, the specific
criteria are:

- All patients have a score ≥4 on at least one Positive and Negative Syndrome Scale
(PANSS; 17) psychosis item (delusions, conceptual disorganization, hallucinatory
behavior, grandiosity, or suspiciousness/persecution)

- All patients have a score ≥4 (moderately ill) on the severity item of the Clinical
Global Impression scale (CGI; 19) at the point of maximum severity of illness to date

Exclusion Criteria:

- organic disease

- severe physical illness

- psychoactive substance dependence

- mental retardation

- pregnancy or breast-feeding patients

- extreme agitation, stupor, negative suicide

- other non-cooperation or risk patients