Childhood Adversity, Genetic Polymorphisms and Stress in First Onset Major Depression

• Status: Completed
• Trial end date: 2013-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The Blue Sky Project, a 5-year study funded by the Canadian Institutes of Health Research, seeks to examine how genetics and early life experiences work together to cause a person's very first onset of depression by increasing sensitivity to stress.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Centre for Addiction and Mental Health
• Collaborator: Queen's University
• Treatments: Citalopram; Dexetimide; Serotonin

Criteria

Inclusion Criteria:

• Current diagnosis of non-psychotic unipolar major depression; first onset

• Between 16 and 29 years of age

• Free of antidepressant treatment for a minimum of two weeks prior to treatment OR on an inadequate antidepressant treatment

• Minimum 8th grade education and fluency in reading English

• Live in the Kingston Area; willing to travel to the Queen's University for appointments

Exclusion Criteria:

• Diagnosis of previous episode(s) of major depression

• Past or present diagnosis of Bipolar Disorder, Schizoaffective Disorder, Schizophrenia, Substance Dependence Disorder, Borderline Personality Disorder, Anti-social Personality Disorder, or Organic Brain Syndrome

• Electroconvulsive Therapy in the past 6 months

• Concurrent serious medical illness judged to be contributing to the depression or impacting on treatment

• Presence of significant suicidal ideation