Chemotherapy in Treating Children With Neuroblastoma
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die. Some tumors become resistant to chemotherapy drugs. Combining
buthionine sulfoximine with chemotherapy may reduce resistance to the drug and allow more
tumor cells to be killed.
PURPOSE: Phase I trial to study the effectiveness of melphalan, buthionine sulfoximine, and
G-CSF in treating children with progressive neuroblastoma that has not responded to previous
therapy.