Overview

Chemotherapy and Surgery Followed by Peripheral Stem Cell Transplantation in Treating Patients With Metastatic Neuroblastoma

Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs to kill more tumor cells. Chemotherapy, given before and after surgery, followed by peripheral stem cell transplantation may be an effective treatment for metastatic neuroblastoma. PURPOSE: Phase II trial to study the effectiveness of chemotherapy, given before and after surgery, followed by peripheral stem cell transplantation in treating patients who have metastatic neuroblastoma.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Children's Cancer and Leukaemia Group
Collaborator:
Societe Francaise Oncologie Pediatrique
Treatments:
Busulfan
Cyclophosphamide
Doxorubicin
Etoposide
Liposomal doxorubicin
Melphalan
Vincristine
Criteria
DISEASE CHARACTERISTICS:

- Histologically or cytologically confirmed primary neuroblastoma OR

- Presence of neuroblasts in bone marrow associated with an elevation of urinary
catecholamines

- Metastatic disease demonstrated by at least 1 of the following:

- Medullary invasion (bone marrow involvement) as indicated by bone uptake on
meta-iodobenzyl guanidine I 123 or bone lesions on bone scan

- Distant metastases to liver, pleura, lungs, or distant nodes

- No 11-22 translocation

PATIENT CHARACTERISTICS:

Age:

- 1 and over

Performance status:

- Not specified

Life expectancy:

- Not specified

Hematopoietic:

- Not specified

Hepatic:

- Not specified

Renal:

- See Disease Characteristics

Other:

- No contraindications to study drugs

PRIOR CONCURRENT THERAPY:

Biologic therapy

- Not specified

Chemotherapy

- No prior chemotherapy

- No other concurrent chemotherapy

Endocrine therapy

- Not specified

Radiotherapy

- Not specified

Surgery

- Not specified