Overview

Chemotherapy and Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Neuroblastoma

Status:
Completed
Trial end date:
2002-02-01
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy or radiation therapy used to kill tumor cells. Combining these therapies may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combining chemotherapy and radiation therapy with or without peripheral stem cell transplantation in treating patients who have neuroblastoma.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Gesellschaft fur Padiatrische Onkologie und Hamatologie - Germany
Treatments:
Carboplatin
Cyclophosphamide
Dacarbazine
Doxorubicin
Etoposide
Ifosfamide
Liposomal doxorubicin
Melphalan
Tretinoin
Vincristine
Vindesine
Criteria
DISEASE CHARACTERISTICS:

- Histologically confirmed neuroblastoma

- Observation stratum:

- MYCN gene not amplified

- Infants with stage I-IVS disease OR

- Over 1 year of age and stage I or II resectable disease

- Standard-risk stratum:

- MYCN gene not amplified

- Infants with serious symptoms and stage II-IVS disease OR

- Over 1 year of age with stage II or III unresectable disease

- High-risk stratum:

- Stage IV disease OR

- Stage I-IVS MYCN gene-amplified disease

PATIENT CHARACTERISTICS:

Age:

- 20 and under

Performance status:

- Not specified

Life expectancy:

- Not specified

Hematopoietic:

- Not specified

Hepatic:

- Not specified

Renal:

- No kidney insufficiency

Cardiovascular:

- No cardiac insufficiency

Other:

- Not pregnant

- Fertile patients must use effective contraception

- No other serious illness

PRIOR CONCURRENT THERAPY:

Biologic therapy:

- Not specified

Chemotherapy:

- No prior chemotherapy within 6 months after diagnosis

Endocrine therapy:

- Not specified

Radiotherapy:

- Not specified

Surgery:

- Not specified