Chemotherapy and Radiation Therapy Plus Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Relapsed or Refractory T-cell Lymphoma, Hodgkin's Lymphoma, or Non-Hodgkin's Lymphoma

• Status: Completed
• Trial end date: 2004-08-01
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage cancer cells. Bone marrow or peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and radiation therapy and kill more cancer cells.

PURPOSE: Phase I/II trial to study the effectiveness of chemotherapy and radiation therapy plus bone marrow or peripheral stem cell transplantation in treating patients who have refractory or relapsed T-cell lymphoma, Hodgkin's lymphoma, or non-Hodgkin's lymphoma.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Northwestern University
• Collaborator: National Cancer Institute (NCI)
• Treatments: Busulfan; Cyclophosphamide; Etoposide

Criteria

DISEASE CHARACTERISTICS:

• Histologically proven relapsed or refractory cutaneous T-cell lymphoma, Hodgkin's lymphoma, or non-Hodgkin's lymphoma of the following types:

• Diffuse small lymphocytic/marginal zone

• Grade I follicular small cleaved cell

• Grade II follicular mixed cell

• Diffuse small cleaved cell

• Grade III follicular large cell

• Diffuse mixed cell

• Diffuse large cell

• Immunoblastic large cell

• HLA identical related donor available

• Phenotypically HLA identical, MLC nonstimulatory donor eligible if no HLA identical related donor is available

• Relapse following autologous bone marrow transplantation allowed if an HLA identical related donor is available

• Eligible for total body irradiation

• No active uncontrolled CNS disease NOTE: A new classification scheme for adult non-Hodgkin's lymphoma has been adopted by PDQ. The terminology of "indolent" or "aggressive" lymphoma will replace the former terminology of "low", "intermediate", or "high" grade lymphoma. However, this protocol uses the former terminology.

PATIENT CHARACTERISTICS:

Age:

• Over 15 to physiologic age 60

Performance status:

• ECOG 0-2

Life expectancy:

• Not specified

Hematopoietic:

• Not specified

Hepatic:

• Not specified

Renal:

• Creatinine no greater than 2.0 mg/dL

Cardiovascular:

• No congestive heart failure

• No myocardial infarction within the past 3 months

• No significant arrhythmia requiring medication

• Resting LVEF normal

Pulmonary:

• No significant nonneoplastic pulmonary disease (e.g., chronic obstructive pulmonary disease) that would preclude therapy with cytotoxic drugs

• DLCO at least 50% of predicted* OR

• FEV1 and/or FVC at least 50% of predicted* NOTE: * Unless due to lymphoma, including Hodgkin's lymphoma

Other:

• Not pregnant

• Negative pregnancy test

• No active serious medical condition that would preclude aggressive cytotoxic chemotherapy

• HIV negative and no clinical evidence of AIDS

PRIOR CONCURRENT THERAPY:

• See Disease Characteristics