Overview

Chemotherapy and Radiation Therapy Plus Bone Marrow Transplantation in Treating Patients With Aggressive Non-Hodgkin's Lymphoma

Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage cancer cells. Bone marrow transplantation may allow doctors to give higher doses of chemotherapy drugs and kill more cancer cells. PURPOSE: Randomized phase III trial to study the effectiveness of chemotherapy and radiation therapy plus bone marrow transplantation in treating patients who have aggressive non-Hodgkin's lymphoma.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Scotland and Newcastle Lymphoma Group
Treatments:
Bleomycin
Carmustine
Cyclophosphamide
Cytarabine
Doxorubicin
Etoposide
Liposomal doxorubicin
Melphalan
Prednisolone
Vincristine
Criteria
DISEASE CHARACTERISTICS:

- Histologically confirmed aggressive non-Hodgkin's lymphoma requiring chemotherapy

- Stage II, III, or IV

- B cell:

- Centroblastic

- Immunoblastic

- Large cell anaplastic

- Non-Burkitt lymphoblastic

- T cell:

- Pleomorphic medium cell

- Pleomorphic large cell

- Immunoblastic

- Large cell anaplastic

- Lymphoblastic

- No Burkitt (L3) subtype

- No large mediastinal mass OR

- Stage I, II, III, or IV

- Bulk disease greater than 10 cm

- Nodal or extranodal site

- No primary localized gut lymphoma

- No CNS involvement

PATIENT CHARACTERISTICS:

Age:

- 15 to 65

Performance status:

- Not specified

Life expectancy:

- Not specified

Hematopoietic:

- No concurrent bone marrow dysplastic syndromes

Hepatic:

- Bilirubin no greater than 2.5 times upper limit of normal (ULN)

Renal:

- Creatinine no greater than 2.5 times ULN

Other:

- No other malignancy except skin cancer or stage I cervical cancer

- Not pregnant

PRIOR CONCURRENT THERAPY:

Biologic therapy:

- Not specified

Chemotherapy:

- See Disease Characteristics

- No prior chemotherapy

Endocrine therapy:

- Not specified

Radiotherapy:

- Not specified

Surgery:

- Not specified