Chemotherapy and Donor Stem Transplant for the Treatment of Patients With High Grade Brain Cancer
Status:
Recruiting
Trial end date:
2025-05-09
Target enrollment:
Participant gender:
Summary
This phase I trial investigates the side effects and effectiveness of chemotherapy followed
by a donor (allogeneic) stem cell transplant when given to patients with high grade brain
cancer. Chemotherapy drugs, such as fludarabine, thiotepa, etoposide, melphalan, and rabbit
anti-thymocyte globulin, work in different ways to stop the growth of tumor cells, either by
killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving
chemotherapy before a donor stem cell transplant helps kill cancer cells in the body and
helps make room in the patient's bone marrow for new blood-forming cells (stem cells) to
grow. When the healthy stem cells from a donor are infused into a patient, they may help the
patient's bone marrow make more healthy cells and platelets and may help destroy any
remaining cancer cells.