Overview

Chemotherapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Persistent Ovarian Epithelial Cancer

Status:
Terminated

Trial end date:
1969-12-31

Target enrollment:

Participant gender:

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy or radiation therapy used to kill tumor cells. It is not yet known whether chemotherapy alone is more effective than chemotherapy plus peripheral stem cell transplantation for ovarian epithelial cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of paclitaxel and carboplatin with that of carboplatin, mitoxantrone, and cyclophosphamide followed by peripheral stem cell transplantation in treating patients who have persistent stage III or stage IV ovarian epithelial cancer.

Phase:

Phase 3

Details

Lead Sponsor:

Gynecologic Oncology Group

Collaborators:

Cancer and Leukemia Group B
Eastern Cooperative Oncology Group
National Cancer Institute (NCI)
Southwest Oncology Group

Treatments:

Albumin-Bound Paclitaxel
Carboplatin
Cyclophosphamide
Mitoxantrone
Paclitaxel