Chemotherapy, Surgery, and Radiation Therapy in Treating Patients With Gastric Cancer
Status:
Completed
Trial end date:
2011-05-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
Combining chemotherapy, radiation therapy, and surgery may kill more tumor cells. E7296 was
conducted to study neoadjuvant chemotherapy and postoperative chemoradiation therapy in
patients diagnosed with high-risk gastric cancer using a new neoadjuvant regimen: paclitaxel
plus cisplatin. It was hypothesized that this new neoadjuvant chemotherapy followed by
surgery and chemoradiation therapy would be well tolerated and would have a high curative
resection rate.