Overview

Chemotherapy Before and After Surgery in Treating Children With Wilm's Tumor

Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving combination chemotherapy before surgery may shrink the tumor so it can be removed during surgery. Giving more chemotherapy after surgery may kill any remaining tumor cells. It is not yet known which chemotherapy regimen after surgery is most effective in treating Wilm's tumor. PURPOSE: Phase III trial to study the effectiveness of chemotherapy before and after surgery in treating children who have Wilm's tumor.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Leicester
Collaborators:
Children's Cancer and Leukaemia Group
Gesellschaft fur Padiatrische Onkologie und Hamatologie - Germany
Societe Francaise Oncologie Pediatrique
Treatments:
Carboplatin
Cyclophosphamide
Dactinomycin
Doxorubicin
Etoposide
Liposomal doxorubicin
Vincristine
Criteria
DISEASE CHARACTERISTICS:

- Diagnosis of one of the following:

- Localized disease

- Unilateral tumor

- Histologically confirmed Wilms' tumor OR

- Clinical and ultrasonic characteristics of nephroblastoma

- No metastasis

- Age 6 months to 17 years at diagnosis

- No prior anticancer therapy

- Metastatic disease

- Unilateral tumor

- Histologically confirmed Wilms' tumor OR

- Clinical and ultrasonic characteristics of nephroblastoma

- Age 18 and under

- No prior anticancer therapy

- Simultaneous bilateral tumors

- No metastases

- No recurrent disease

- No other renal tumors

PATIENT CHARACTERISTICS:

Age

- See Disease Characteristics

- 18 and under

Performance status

- Not specified

Life expectancy

- Not specified

Hematopoietic

- Not specified

Hepatic

- Not specified

Renal

- Not specified

Other

- No social or geographical reasons that would preclude study

- No other associated pathology that would preclude study

PRIOR CONCURRENT THERAPY:

Biologic therapy

- Not specified

Chemotherapy

- No prior chemotherapy

Endocrine therapy

- Not specified

Radiotherapy

- No prior radiotherapy

Surgery

- No prior surgery

- No requirement for emergency or immediate surgery for any reason