Chemoradiotherapy in Elderly Patients With Oesophagus Cancer
Status:
Recruiting
Trial end date:
2026-04-01
Target enrollment:
Participant gender:
Summary
Management of elderly patient with cancer is a therapeutic challenge and a public health
problem. The mean age of esophageal cancer is 64.5 years and 72.1 years in men and women
respectively. Surgery is a standard treatment reserved to about 30 % of patients. The other
70 % are considered unfit for surgery for various reasons, including ageing.
Chemoradiotherapy (CRT) is standard treatment for patients with esophageal cancer unfit for
surgery. The validated treatment scheme is external beam radiotherapy (EBRT) 50 Gy over 5
weeks combined with cisplatin and 5FU infusion. However it induces high rates of severe and
life threatening toxicities: grade 3 haematologic and esophageal mucositis of 20 and 25 %
respectively, in patients with a median age of 64 years. CRT has not been properly evaluated
in patients more than 75 years, and other combined chemotherapy are challenging.