Chemoprevention of Prostate Cancer, HDAC Inhibition and DNA Methylation
Status:
Completed
Trial end date:
2015-12-01
Target enrollment:
Participant gender:
Summary
The objective of the study is to identify mechanisms by which compounds found in cruciferous
vegetables alter gene expression via epigenetic modifications (changes in gene expression)
and may prevent prostate cancer development.
The investigators have found that sulforaphane (SFN), an isothiocyanate found in cruciferous
vegetables, inhibits histone deacetylase (HDAC) activity in human colorectal and prostate
cancer cells.
Phase:
N/A
Details
Lead Sponsor:
Portland VA Medical Center
Collaborators:
National Cancer Institute (NCI) OHSU Knight Cancer Institute Oregon State University