Characterizing the Incretin Effect of Amino Acids and Defining GLP-1 Role on Skeletal Muscle
Status:
Completed
Trial end date:
2018-03-01
Target enrollment:
Participant gender:
Summary
This study has two protocols the aims of which are:
1. To identify age-related effects of AA on incretin secretion and whether and to what
extent AA exhibit a true incretin effect (gut- mediated increases in plasma insulin) in
younger individuals. (Protocol 1)
2. To define the extra-pancreatic ''novel'', insulin independent effects of glucagon like
peptide-1 (GLP-1) on postprandial muscle protein and glucose metabolism and
microvascular blood flow. (Protocol 2)