Characterization of the Toll-like Receptor 7-agonist Imiquimod 3.75% as a New Surrogate Model of Itch
Status:
Withdrawn
Trial end date:
2022-06-01
Target enrollment:
Participant gender:
Summary
The aim of this research project is to design a new model of human itch by application of
Zyclara cream. Further, the aim is to characterize the model and to verify if the mechanism
of action of imiquimod follows the histaminergic or non-histaminergic pathway by using the
anti-histamine drug doxepin. The last goal is to evaluate the interaction between the
activation of TLR7 receptor and the activation of TRPA1 and TRPM8 receptors, which are two of
the most important receptors involved in the transduction of noxious stimuli, and to evaluate
to which extent these three channel populations functionally overlap.