Characterization of Pain Processing Mechanisms in Irritable Bowel Syndrome
Status:
Completed
Trial end date:
2006-03-01
Target enrollment:
Participant gender:
Summary
This study is being done to collect new information on irritable bowel syndrome, a disease
that causes abdominal pain that does get better with treatment or keeps coming back
("chronic"). To better understand what causes the irritable bowel syndrome, we are studying
drugs used to treat pain, dextromethorphan, naloxone, fentanyl, and lidocaine. We will study
the effects these drugs have on experimental pain.
Dextromethorphan is used in non-prescription cough syrups. Naloxone is used for reversing the
effects of narcotic pain relievers. Fentanyl is a narcotic used to treat pain and to make a
person relaxed (sedated) before anesthesia. The purpose of this study is to see what kinds of
pain are affected by these drugs in persons who have irritable bowel syndrome and persons who
do not have this problem.
Phase:
Phase 2
Details
Lead Sponsor:
US Department of Veterans Affairs VA Office of Research and Development