Changing to Nonprotease Inhibitor Treatment to Improve Side Effects
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
The purpose of this study is to learn whether changing from a type of anti-HIV drug called a
protease inhibitor (PI) to another type of anti-HIV drug will help to lower the amount of
fats or sugars in the blood.
PIs have been effective at keeping HIV viral load (amount of HIV in the blood) down. However,
some people who take PIs have higher than normal levels of fats and/or sugars in the blood.
Doctors believe that switching to anti-HIV drugs that do not contain PIs will improve the
abnormal side effects. This study will test 3 different combinations of non-PI drugs to see
which may improve side effects while keeping viral loads low.
Phase:
Phase 2
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Treatments:
Abacavir Dideoxynucleosides Efavirenz Lamivudine Lamivudine, zidovudine drug combination Nevirapine Zidovudine