Changes in Resistome After Dental Extraction and Amoxicillin.
Status:
Unknown status
Trial end date:
2018-03-01
Target enrollment:
Participant gender:
Summary
The aim of this study is to evaluate the nature of the change in oral and gut bacterial
resistance profiles after antibiotic therapy for a surgical procedure in two groups. The
intervention group will receive a course of amoxicillin and analgesics after surgical
extraction and have bacterial samples taken from saliva, tongue coatings and stool samples at
four appointments over a period of six months. This will be compared to the control group
which receive only analgesics after the surgical extraction.
An examination of the development and sustainability of antibiotic resistance in the oral and
gut microbiome of healthy cohorts will be followed up for 6 months, after surgical extraction
of impacted teeth.
Change in proportion of antibiotic resistant bacterial components will be studied using
Metagenomic DNA sequencing and quantification of resistant genes .