Changes in Plaque Characteristics After Short-term Statin Therapy as Assessed With Coronary CT
Status:
RECRUITING
Trial end date:
2028-12-15
Target enrollment:
Participant gender:
Summary
INTENSE Trial is a prospective, double-blind, randomized, placebo-controlled, single-center study with two arms (40 mg intensified statin therapy vs matching placebo for rosuvastatin) among statin-naive patients referred to coronary CT angiography due to stable chest pain, followed for 24 months by using a photon-counting detector CT (PCD-CT).
INTENSE Trial aims 1) to assess the effect of short-term intensified statin therapy on coronary anatomy and physiology using PCD-CT and 2) to determine the impact of short-term, intensified statin therapy on coronary plaque morphology and hemodynamics to identify statin responder and non-responder patients in addition to testing the hypothesis of "plaque memory" after the 24-month follow-up period.
Phase:
NA
Details
Lead Sponsor:
Prof. Maurovich-Horvat Pál
Collaborators:
HeartFlow, Inc. National Research, Development and Innovation Office, Hungary