Changes in Myocardial Biomechanics and Early Short-term Doxycycline Therapy in Patients With Primary Anterior STEMI

• Status: Unknown status
• Trial end date: 2017-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to investigate the changes of myocardial biomechanics and efficacy of doxycycline in patients with primary anterior STEMI.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Russian Academy of Medical Sciences
• Treatments: Doxycycline

Criteria

Inclusion Criteria:

• age ≥ 18 and ≤ 75 years at time of randomization (18 years and older)

• ST-elevation Q wave myocardial infarction

• term admission to an intensive care unit (ICU) in the first 24 hours of onset

• the reperfusion of the infarct-related coronary artery is not later than 24 hours after the initial onset of acute transmural myocardial infarction

• written the informed consent to participate in research

Exclusion Criteria:

• atrial fibrillation, a permanent form

• valvular heart disease

• severe comorbidity

• acute heart failure according to the Killip classification IV FC (functional class)

• history of chronic heart failure (NYHA III-IV)

• poor image quality for Echocardiography

• sinus bradycardia - heart rate of under 50 beats per minute, interventricular conduction delay (QRS > 0,11 s.) and atrioventricular block II-III degree