Changes in Knee Articular Cartilage Volume in Women on Aromatase Inhibitors
Status:
Completed
Trial end date:
2011-12-01
Target enrollment:
Participant gender:
Summary
Many women with breast cancer are treated with a class of drugs called aromatase inhibitors
(mainly letrozole or anastrozole), which lowers the amount of estrogen being produced in the
body. Women on aromatase inhibitors appear to experience joint pains and arthralgia. The aim
of this study is to determine whether the joint pains experienced by some women on aromatase
inhibitors is associated with more defects in their cartilage, compared to women not
receiving this therapy. Using the magnetic resonance imaging (MRI) technique, the knee joint
will be examined to assess changes in cartilage volume over time.