Changes in Gastrointestinal Microbiota Using VSL#3 in Patients With IBS-D
Status:
Unknown status
Trial end date:
2012-12-01
Target enrollment:
Participant gender:
Summary
Aim
To compare changes in gut microbiota of IBS patients and healthy controls using next
generation sequencing method like Illumina sequencing based on 16S rDNA profiling.
The major objectives of the study are:
To characterize type of bacterial species and compare diversity of the host's gut microbiota
in 20 Irritable bowel syndrome (IBS) patients with 16 healthy controls (HCs) using high
through put culture-independent method like Illumina sequencing.
To study modulation of gut microbiota profile after treatment with probiotics (VSL #3) for 8
weeks.
To study the improvement of symptoms after modulation of gut microbiota with probiotics (VSL
#3) for more than 8 weeks.