Changes in Endothelial Function and Biomarkers in African Americans (AA) With Metabolic Syndrome

• Status: Unknown status
• Trial end date: 2011-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to compare the effects of Azor (a combination of amlodipine and olmesartan) with Hyzaar ( a combination of losartan and hydrochlorothiazide) on the thin lining on the inside of blood vessels. These cells help keep blood vessels healthy and blood pressure normal.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: InVasc Therapeutics, Inc.
• Treatments: Amlodipine; Amlodipine Besylate, Olmesartan Medoxomil Drug Combination; Hydrochlorothiazide; Losartan; Olmesartan; Olmesartan Medoxomil; Spironolactone

Criteria

Inclusion Criteria:

• African American

• Hypertension and one of the following:

• Fasting glucose > 100 mg/dl

• HgA1C> 6.0 %

• Plasma triglycerides >150

• HDL cholesterol < 40 mg/dl in men or < 50 mg/dl in women

Exclusion Criteria:

• History of Heart failure

• use of insulin

• non-dominant arm circ > 50 cm.