Overview

Changes in Dopamine Levels Before and After Weight Restoration in People With Anorexia Nervosa

Status:
Completed
Trial end date:
2015-12-01
Target enrollment:
0
Participant gender:
All
Summary
This study will use positron emission tomography imaging to investigate changes in dopamine systems in people with anorexia nervosa before and after weight restoration.
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
New York State Psychiatric Institute
Collaborator:
National Institute of Mental Health (NIMH)
Treatments:
Dopamine
Dopamine Agents
Methylphenidate
Raclopride
Criteria
Inclusion Criteria:

Participants with AN:

- Meets DSM-IV criteria for AN or ED-NOS (meets criteria for AN except amenorrhea)

- Sufficiently medically and psychiatrically stable to leave inpatient unit, as assessed
by clinical team

Healthy control participants:

- No current or past psychiatric illness

- Between 80% and 120% of ideal body weight

Exclusion Criteria:

All participants:

- Current use of psychotropic medication such as antipsychotics or antidepressants

- Pregnant or breastfeeding

- History of a substance use disorder

- Significant medical illness

- High blood pressure (resting systolic blood pressure greater than 140 mmHg and
diastolic blood pressure greater than 90 mmHg)

- Current or lifetime history of schizophrenia, bipolar disorder, or other psychotic
disorder as defined by DSM-IV-TR

- Metal implants or paramagnetic objects contained within the body that may interfere
with the MRI scan, as determined in consultation with a neuroradiologist and according
to specified reference book guidelines

- Exposed to radiation in the workplace or has had a nuclear medicine procedure during
the 1 year before study entry

- Previous adverse reaction to psychostimulants