Change of Airway Hyperresponsiveness to Mannitol and Methacholine in Patients With Asthma

• Status: Completed
• Trial end date: 2012-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Control of airway inflammation is the cornerstone of asthma management. The aim of the present pilot study was to assess whether, and in which magnitude, a leukotriene receptor antagonist (LTRA) added to a basic treatment of inhaled corticosteroids (ICS) + long-acting betamimetics (LABA) might improve airway hyperresponsiveness and inflammation in well-controlled patients with asthma.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Cantonal Hosptal, Baselland; University Hospital, Basel, Switzerland
• Treatments: Mannitol; Methacholine Chloride; Montelukast

Criteria

Inclusion Criteria:

• clinically well-controlled asthma

Exclusion Criteria:

• Smokers

• women planning a pregnancy or pregnant

• patients with any significant illness