Change in Permeability of the Small Intestine After Treatment With Gluten

• Status: Completed
• Trial end date: 2016-09-19
• Target enrollment: 0
• Participant gender: All

Summary

The overall hypothesis of this research study is that gluten intake alters intestinal barrier function in patients with Irritable Bowel Syndrome (IBS) diarrhea who also exhibit non-celiac gluten sensitivity (NCGS).

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Mayo Clinic

Criteria

Inclusion Criteria:

1. Non celiac gluten sensitive patients with a functional bowel disorder

2. Age 18 to 70 years.

Exclusion Criteria:

1. Positive serum tissue transglutaminase (TTG) Immunoglobulin A (IgA) positive or medical record of small bowel biopsy suggestive of celiac disease.

2. Use of tobacco products within the past 6 months (since nicotine may affect intestinal permeability).

3. Abdominal surgeries (except appendectomy, cholecystectomy and vaginal hysterectomy or tubal ligation)

4. Use of Nonsteroidal Anti-inflammatory Drugs(NSAIDs) or aspirin within the past week (since Nonsteroidal Anti-inflammatory Drugs (NSAIDs) affect intestinal permeability).

5. Use of oral corticosteroids within the previous 6 weeks.

6. Ingestion of artificial sweeteners such as Sucralose, Nutrasweet ™ (aspartame), lactulose or mannitol 2 days before the study tests begins, e.g., foods to be avoided are sugarless gums or mints and diet soda.

7. Bleeding disorders or medications that increase risk of bleeding from mucosal biopsies.

8. High anxiety or depression score (>11 on each subscale) on the Hospital Anxiety Depression Score questionnaire.

9. Known allergy to fluorescein.