Cetylpyridium Chloride (CPC) Based Chewing Gum and Gingivitis
Status:
Completed
Trial end date:
2018-09-08
Target enrollment:
Participant gender:
Summary
This placebo-controlled, double-blinded, randomized crossover study evaluates the plaque and
gingivitis reducing capacity of Cetylpyridium Chloride (CPC) chewing gum, with mechanical
oral hygiene. The study will enroll 73 students, faculty, and staff from the UTHealth School
of Dentistry. Half of the eligible participants will be randomly assigned to get the CPC gum
in the first treatment period (21 days), a wash-out period of 21 days, and then a placebo gum
in the second treatment period (21 days). The other half will be assigned to follow the same
schedule but with the treatment reversed. A statistician will perform the randomization.
Primary outcomes are assessed by validated tools, such as the Plaque Index (PI), Gingival
Index (GI), and percent of bleeding sites on probe (BOP).
Phase:
Phase 4
Details
Lead Sponsor:
The University of Texas Health Science Center, Houston