Cetuximab and Simvastatin in Treating Patients With Advanced or Metastatic Colorectal Cancer
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
RATIONALE: Monoclonal antibodies, such as cetuximab, can block tumor growth in different
ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and
help kill them or carry tumor-killing substances to them. Simvastatin may stop the growth of
tumor cells by blocking some of the enzymes needed for cell growth. Simvastatin may help
cetuximab work better by making tumor cells more sensitive to cetuximab. Giving cetuximab
together with simvastatin may kill more tumor cells.
PURPOSE: This phase II trial is studying giving cetuximab together with simvastatin in
treating patients with advanced or metastatic colorectal cancer.