Overview

Cervical Cancer Radiotherapy by Use of VMAT, Individualized Polyradiosensitization and Interstitial Brachytherapy

Status:
Unknown status
Trial end date:
2020-12-01
Target enrollment:
0
Participant gender:
Female
Summary
The purpose of this study is to define an effectiveness of concurrent chemoradiotherapy of cervical cancer patients treated by VMAT (volumetric arc therapy) based external beam radiotherapy, polyradiosensitization by cisplatin and gemcitabine and interstitial brachytherapy.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
The National Center of Oncology, Azerbaijan
Treatments:
Cisplatin
Gemcitabine
Criteria
Inclusion Criteria:

Histologically confirmed primary invasive carcinoma of the uterine cervix Previously
untreated disease Any cell type Stage IB2, IIA, IIB, IIIA, IIIB, or IVA Para-aortic lymph
nodes negative by radiologic evaluation or by biopsy if CT scan is suspicious for
adenopathy No known metastases to scalene nodes or other organs outside the radiotherapy
field Study enrollment within 8 weeks of diagnosis Performance status - GOG 0-2 Absolute
neutrophil count at least 1,500/mm^3 Platelet count at least 100,000/mm^3 Bilirubin no
greater than 1.5 times normal SGOT no greater than 3 times normal Creatinine less than 2.0
mg/dL No renal abnormalities (e.g., pelvic kidney, horseshoe kidney, or renal
transplantation) that would require modification of radiotherapy fields No bilateral
ureteral obstruction allowed unless treated with stent or nephrostomy tube Not pregnant
Fertile patients must use effective contraception No septicemia or severe infection No
circumstance that would preclude study completion or follow-up No other malignancy within
the past 5 years except nonmelanoma skin cancer No prior cytotoxic chemotherapy No prior
pelvic or abdominal radiotherapy No prior therapy for this malignancy

Exclusion Criteria:

Pregnancy or Breast-Feeding: Pregnant or breast-feeding women will not be entered on this
study due to risks of fetal and teratogenic adverse events.(Note: Serum Pregnancy tests
must be obtained in women of child bearing potential). Sexually active females may not
participate unless they have agreed to use an effective contraceptive method (such as
abstinence, diaphragm, condom, or intrauterine device) to prevent pregnancy for the
duration of the study.

Growth factor(s): Growth factors that support platelet or white cell number or function
must not have been administered within the past 28 days.

Erythropoietic drug(s): Erythropoietin or related hormones must not have been administered
within the past 28 days.

Infection: Patients who have an uncontrolled infection. Evidence of distant metastases
Prior invasive malignancy (except non-melanomatous skin cancer), unless disease free for a
minimum of 3 years.

Prior systemic chemotherapy within the last three years. Prior radiotherapy to the pelvis