Cerebrovascular Reactivity in American Football Players
Status:
Recruiting
Trial end date:
2022-09-01
Target enrollment:
Participant gender:
Summary
Investigators will measure cerebrovascular reactivity (CVR) using functional near-infrared
spectroscopy (fNIRS) and magnetic resonance imaging (MRI) during the chronic phase after
repetitive mild traumatic brain injury (rmTBI) as a biomarker of traumatic cerebrovascular
injury (TCVI). We hypothesize that CVR will be decreased in patients with rmTBI and that
these decreases will correlate with clinical outcomes. Furthermore, we predict that 5 week
administration of a phosphodiesterase 5 (PDE5) inhibitor, sildenafil citrate, will augment
CVR in patients with a history rmTBI.