Cerebral Hemodynamic Optimization by Milrinone to Prevent Delayed Cerebral Ischemia
Status:
Recruiting
Trial end date:
2024-07-01
Target enrollment:
Participant gender:
Summary
The present study is a randomized, multi-center, double-blind, prospective study that tests
the efficacy of intravenous milrinone to optimize cerebral hemodynamic and prevent delayed
cerebral ischemia (DCI) during the high-risk period (day 4- day 14) in patients with severe
subarachnoid hemorrhage due to intracranial aneurysm rupture (SAHa) (WFNS IV-V). The main
objective is to evaluate, in comatose patients and / or sedated on D3 following a severe SAHa
(WFNS IV -V), the effect of 10 days of milrinone versus placebo, in addition to the usual
management, on the volume of DCI lesions measured on CT scan at 1 month.