Central Mechanisms That Regulate Glucose Metabolism in Humans
Status:
Active, not recruiting
Trial end date:
2022-12-01
Target enrollment:
Participant gender:
Summary
Type 2 diabetes is a chronic condition that affects the ability of the body to regulate
glucose (sugar). When glucose levels are low, the liver can make glucose to increase levels
in the body. This important process is called endogenous glucose production (EGP). Previous
studies suggest that the central nervous system (CNS), including the brain, helps to
coordinate this process by communicating with the liver through potassium channels. Control
of EGP can be impaired in people with type 2 diabetes, which may contribute to the high
levels of glucose seen in these individuals.
The purpose of this study is to understand how activating these potassium channels in the
control centers of the brain with a medication called diazoxide might inhibit the amount of
glucose made by the liver. This is particularly important for people with diabetes who have
very high production of glucose, which in turn causes hyperglycemia (high levels of sugar in
the blood) that leads to diabetes complications.
Phase:
Phase 4
Details
Lead Sponsor:
Albert Einstein College of Medicine Albert Einstein College of Medicine of Yeshiva University
Collaborators:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Institutes of Health (NIH)