Cefuroxime vs Ceftriaxone for SSI Prevention in Neurosurgery
Status:
Recruiting
Trial end date:
2022-07-01
Target enrollment:
Participant gender:
Summary
BACKGROUND: Surgical site infection (SSI) is potentially catastrophic in neurosurgical
procedures, causing poor in-hospital outcomes in more than half of those affected and
significantly increased length of hospital stay. The appropriate and timely use of
prophylactic antibiotics is found to reduce the prevalence of SSIs. At present, several
regimen of antimicrobial agents are used in neurosurgical procedures since the choice of
appropriate antibiotic agent is not fully established. Cephalosporins are among the
frequently used antibiotics for prophylaxis in neurosurgical procedures, with studies
comparing first and second generation Cephalosporins to third generation in neurosurgical
prophylaxis, showing no superiority of the latter over the former. Clearly, comparing
Cefuroxime (a second generation Cephalosporin) to Ceftriaxone (a third generation
Cephalosporin) in neurosurgical procedures will provide more knowledge on the efficacy of
Cefuroxime as antibiotics prophylaxis.
OBJECTIVE: The study aimed to determine the comparative efficacy of cefuroxime versus
ceftriaxone in the prevention of surgical site infection after neurosurgical procedures at
the University College Hospital Ibadan, Nigeria.
METHODS: The study will be a randomized controlled trial recruiting 92 participants.
Participants would be patients undergoing neurosurgical procedures; they will be randomized
to treatment arms (those receiving cefuroxime versus ceftriaxone for antibiotic prophylaxis).
All the study articipants will be followed up for 30 days to assess for the development of
surgical site infection.
DATA ANALYSIS: Data will be collated, computed and analyzed using the Statistical Product and
Service Solutions (SPSS) Version 21. Demographics will be presented using summary statistics;
mean +/- standard deviation and figures (e.g pie chart, histogram). Study outcomes will yield
categorical and continuous variables which will be analyzed using chi-squared test and Z-test
and/or T-test for hypothesis testing.