Ceftriaxone Vs Levofloxacin on Cytokine Expression in Pneumococcal Pneumonia

• Status: Terminated
• Trial end date: 2005-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare levofloxacin vs ceftriaxone impact on the cytokine production in patients with pneumococcal pneumonia.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hospital Mutua de Terrassa
• Collaborator: Fondo de Investigacion Sanitaria
• Treatments: Ceftriaxone; Levofloxacin; Ofloxacin

Criteria

Inclusion Criteria:

• patients with an acute febrile respiratory illness accompanied by a new radiographic infiltrate consistent with this diagnosis.

• and with a confirmed pneumococcal aetiology

Exclusion Criteria:

• age < 18 years,

• pneumonia distal to endobronchial obstruction,

• pulmonary tuberculosis,

• bronchiectasis,

• known allergy to B-lactams or fluoroquinolones,

• underlying systemic autoimmune disease

• immunocompromised states including patients on maintenance oral corticosteroids, HIV infection,

• pregnancy,

• patients that received antimicrobial therapy in the 15 days preceding the current episode and those who had received fluoroquinolones in the last month, or non steroidal anti-inflammatory therapy in the last two weeks.

• Patients with renal failure (serum creatinine > 2 mg / dL),

• and patients with a documented pneumococcal pneumonia in the previous 4 weeks